Comparative Characteristics of Structural and Functional Changes in the Hippocampal CA<sub>3</sub> Region in White Rats After Acute Ischemia and Brain Injury

The aim of the study was to pyramidal neurons and astrocytes hippocampal CA 3 region in dynamics white rats after acute ischemia severe traumatic brain injury. Material methods. Acute simulated by 20-minute occlusion common carotid arteries (CCA), injury (TBI) a free-falling weight impact. Nissl staining, hematoxylin eosin immunohistochemical reactions for NSE, MAP-2, p38, GFAP were used study. proliferative activity cells assessed using Ki-67 response. carried out on thin (4 μm) serial frontal sections animals control group (animals without pathological factors, n=5) 1, 3, 7 14 days experimental modeling CCA (n=20) TBI (n=20). Morphometric analysis performed ImageJ 1.52s software. relative area edema-swelling zones neuropil, number density neurons, content dystrophic necrobiotically altered with one or more nucleoli, proliferating cells, large trunks dendrites, total giant synaptic terminals stratum lucidum detected. distribution variation series, verification statistical hypotheses, construction graphs Statistica 8.0 software R. Results. Mortality between groups did not differ exceed 7%. In day TBI, there statistically significant increase volume edema-swelling, decreased, but change. days, mechanisms neuroglio- plasticity activated. two nucleoli increased, hypertrophied cytoskeleton damaged restored, interneuronal synapses increased. During period from decreased 16.3%, – 33.7% (p=0.001). Pathological compensatory-restorative changes diffuse-focal nature pronounced TBI. Conclusion. Thus, same type focal heterochronous heteromorphic dystrophic, necrobiotic nervous tissue observed region. Structural functional recovery occurred together decrease numerical tissue. More combined revealed considered as basis standard permanent reorganization hippocampus postischemic post-traumatic periods.